Metrotexate

Resumen

Alternativas con registro en Colombia

• Pemetrexed · costo anual estimado $ 123.370
• Pralatrexato · costo anual estimado $ 1.167.011.945

Estudios clínicos principales

• A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheuma
  Fase 3 · 2009 · 556 participantes · Hoffmann-La Roche · NCT00810199 · PubMed 22562983 · PubMed 24473673
• C-early: A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in
  Fase 3 · 2012 · 359 participantes · UCB Pharma · NCT01521923 · PubMed 27165179 · PubMed 28666080
• 22-00: Low-dose Oral Cyclophosphamide and Methotrexate Maintenance for Hormone Receptor-negative Early Breast Cancer
  Fase 3 · 2000 · 1.086 participantes · ETOP IBCSG Partners Foundation · NCT00022516 · PubMed 27325862 · PubMed 27372069
• A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTX
  Fase 3 · 2013 · 718 participantes · Hoffmann-La Roche · NCT01855789

Enfermedades relacionadas

• Enfermedad inflamatoria intestinal (Crohn, colitis)
• Infecciones por hongos
• Artritis reumatoide
• Psoriasis y artritis psoriásica
• Cáncer (todos)
• Cáncer de mama
• Cáncer de cabeza y cuello
• Leucemias
• Linfomas
• Sarcomas y GIST

Fuentes

• Etiqueta FDA (DailyMed): METHOTREXATE
• EMA: Nordimet
• EMA: Jylamvo